Scientific program
March 26 - NICOLAE IORGA HALL - Translational Research Foundations & Drug Development Pathways
09:00 - 09:15
Opening
Welcome and Opening Remarks
Viorel Jinga, Cătălina Poiana, Dana Lucia Stanculeanu, Elena-Ioana Braicu, Jalid Sehouli, Gheorghe Peltecu
09:15 - 10:25
Key Session
Translational Research: From Concept to Clinical Application
Chairs Ioana Berindan Neagoe, Delia Mezzanzanica
- 09:15 - 09:35 The Role of microRNAs in Cancer Development and Therapeutic Targeting George Calin
- 09:35 - 10:00 Microenvironmental Changes as Therapeutic Targets in Early Ovarian Cancer Genesis Mihnea Dragomir
- 10:00 - 10:10 Discussion
- 10:10 - 10:25 Ewo Pharma Symposium: Second-Line Options Expand Beyond Chemotherapy in Endometrial Cancer Dana Stanculeanu
10:25 - 10:45
Break
Coffee Break & Industry Exhibition
10:45 - 12:45
Scientific Session
Liquid Biopsies: From Research Tool to Clinical Decision-Making
Chairs Delia Mezzanzanica, Irina Cazacu-Croitoru
- 10:45 - 11:05 Circulating Tumor DNA: Clinical Validation and Implementation Victor Velculescu
- 11:05 - 11:25 Transcriptional Changes Associated with Tumor Presence Detected in Liquid Biopsy Ioana Berindan Neagoe
- 11:25 - 11:45 Translating Liquid Biopsy into Real-World Clinical Decisions Adelina Silvana Gheorghe
- 11:45 - 12:00 Discussion
- 12:00 - 12:45 MSD Symposium Cervical Cancer Across the Care Continuum: From Prevention to Treatment Dana Lucia Stanculeanu, Gheorghe Peltecu, Serban Nastasia
12:45 - 13:30
Break
Lunch Break
13:30 - 15:15
Scientific Session
Drug Development Journeys: Phase I to Market
Chairs Elena-Ioana Braicu, Dan Jinga, Dana-Lucia Stanculeanu
- 13:30 - 13:50 PARP Inhibitors: From First-in-Human Studies to Pan-Gynecologic Applications Jonathan Ledermann
- 13:50 - 14:10 Bevacizumab Across Gynecologic Cancers: From Phase I to Standard of Care Nicoletta Colombo
- 14:10 - 14:30 Checkpoint Inhibitors: Phase I Discoveries to Gynecologic Oncology Approvals Phillipp Harter
- 14:30 - 14:45 Discussion
- 14:45 - 15:00 Pharma& symposium - New horizons in PARPi for patients with Advanced Ovarian Cancer Elena-Ioana Braicu
- 15:00 - 15:15 Stada Symposium - Bone Health Matters: Optimizing the Management of Bone Metastases with Zvogra (denosumab) Dragos Median
15:15 - 15:25
Break
Coffee Break & Industry Exhibition
15:25 - 16:35
Scientific Session
Biomarker Development and Cross-Sector Learning
Chairs Dragos Median, Mircea Dediu
- 15:25 - 15:45 Are Biomarkers Valid or Is Our Approach Incorrect? The HER2 vs. FRA Story Delia Mezzanzanica
- 15:45 - 16:05 HRD Testing: From Discovery to Clinical Implementation Daniela Zob
- 16:05 - 16:25 HER2-Targeted Therapy: Lessons from Breast Cancer for Gynecologic Oncology Dennis Slamon
- 16:25 - 16:35 Discussion
16:35 - 18:05
Symposium
Industry-Sponsored Symposium
- 16:35 - 16:55 BMS Symposium- Medical Hub
Where Legacy Meets Innovation: From Classic Biomarkers to New Therapeutic Mechanisms in TNBC Mircea Dediu - 16:55 - 17:35 BMS Symposium- Medical Hub
Biomarkers Testing Across Pathologies: From Diagnosis to Treatment Decisions Dana Lucia Stanculeanu, Claudia Burz - 17:35 - 18:05 Industry Symposium Gilead: Bridging guidelines and practice: Expert consensus on mTNBC and HR+/HER2– in Romania Dragos Median
18:05 - 18:15
Wrap-Up
Day 1 Summary and Key Insights
March 27 - NICOLAE IORGA HALL - Resistance Mechanisms & Therapeutic Evolution
08:45 - 09:10
Scientific Session
Welcome address by the Minister of Health and overview of Romania’s cancer care initiatives
09:00 - 10:25
Scientific Session
Understanding and Overcoming Resistance
Chairs Cornelia Nitipir, Gabriel Kacso
- 09:00 - 09:20 Years of Insights into Platinum-Based Resistance: From Discovery to Clinical Management James Brenton
- 09:20 - 09:40 PARP Inhibitor Resistance: Laboratory Discovery to Clinical Solutions Daniela Matei
- 09:40 - 09:55 Discussion
- 09:55 - 10:25 Eli Lilly Symposium: What Does Platinum Sensitivity Mean After PARP Inhibitors in Ovarian Cancer? Elena Ioana Braicu
10:25 - 10:40
Break
Coffee Break & Industry Exhibition
10:40 - 10:55
Scientific session
- 10:40 - 10:55 Translating Health Science for the Public Daniel Nagel
10:55 - 12:35
Industry-Sponsored Symposium
- 10:55 - 11:55 Educational session organized with the support of Abbvie - Redefining Possibilities:Mirvetuximab Soravtansine and the PROC challenge Jalid Sehouli, Mihnea Dragomir, Constantin Volovat, E. Ioana Braicu, Dana Stanculeanu, Dragos Median
- 11:55 - 12:35 AstraZeneca Symposium: Endometrial Cancer Treatment in the Molecular Era Nicoletta Colombo, Elena. Ioana Braicu
12:35 - 13:10
Break
Lunch Break
13:10 - 14:10
Conferral Ceremony
Conferral Ceremony
- 13:10 - 14:10 Conferral Ceremony of the Title Doctor Honoris Causa of the Carol Davila University of Medicine and Pharmacy to Prof. Dr. Dennis Slamon Prof. Dr. Viorel Jinga
14:10 - 15:40
Scientific Session
Next-Generation Therapeutics
Chairs Gottfied Koneczny, Dana-Lucia Stanculeanu, Mircea Dediu
- 14:10 - 14:30 CAR-T Therapy for Solid Tumors: Early Phase Progress? Oliver Dorigo
- 14:30 - 14:50 Bispecific Antibodies: Principles, Targets and Limitations Frederik Marmé
- 14:50 - 15:10 AI-Designed Therapeutics: Predicting Patient Response Christiane Hoeper
- 15:10 - 15:30 Diversity in Early Clinical Trials: Patient Perspectives Jalid Sehouli
- 15:30 - 15:40 Discussion
15:40 - 15:50
Break
Coffee Break
15:50 - 16:50
Symposium
Industry Symposium
- 15:50 - 16:50 AstraZeneca Symposium: Bridging Evidence and Practice in Breast Cancer. Connecting the dots to redefine clinical impact Dana Lucia Stanculeanu, Cornelia Nitipir, Dragos Median
16:50 - 18:25
Scientific Session
Treatment Optimization and Patient-Centered Care
Chairs Michael Birrer, Radu Vidra
- 16:50 - 17:10 Optimizing Treatment Sequences in Endometrial Cancer Michael Birrer
- 17:10 - 17:30 Optimizing Treatment Sequences in Ovarian Cancer Robert Coleman
- 17:30 - 17:50 Mismatch Repair Alterations in Gynecologic Cancers: When Does It Change Clinical Management? Radu Vidra
- 17:50 - 18:10 Merck Symposium: Fertility preservation for medical reasons Cezara Bucur
- 18:10 - 18:25 REGENERON | MEDISON Symposium: Quality of Life and Survival in Recurrent or Metastatic Cervical Cancer: Insights from EMPOWER Cervical 1 Dragos Median
March 28 - NICOLAE IORGA HALL -ADC Innovation, Global Perspectives & Hub Development
08:30 - 09:45
Scientific Session
Antibody-Drug Conjugates: From Design to Clinical Success
Chairs Sven Mahner, Daniela Zob, Claudia Burz
- 08:30 - 08:50 ADC Design Principles: From Biomarker Identification to Payload Selection Gottfried Konecny
- 08:50 - 09:10 Mechanisms of Resistance to ADCs: Laboratory Insights to Clinical Management? Toon Van Gorp
- 09:10 - 09:30 ADC Combination Strategies: Rational Design and Clinical Implementation Nicum Shibani
- 09:30 - 09:45 Discussion
09:45 - 10:30
Symposium
Industry-Sponsored Symposium
- 09:45 - 10:30 Tubulis Symposium: Novel linkers to unlock the therapeutic potential of ADCs in ovarian cancer and beyond Jonas Helma-Smets
10:30 - 11:00
Break
Coffee Break & Industry Exhibition
11:00 - 12:30
Scientific Session
Surgery vs. chemotherapy. When to Cut, When to Treat, and When to Turn Up the Heat
Chairs Alexandru Blidaru, Gabriel Dimofte
- 11:00 - 11:20 Beyond the OR: Pitfalls and Successes in Surgical Trials?Insights from LION & TRUST. Sven Mahner
- 11:20 - 11:40 HIPEC vs. Alternatives: IP Chemo, PIPAC, or Systemic-Only? Octav Ginghina
- 11:40 - 12:00 TRUST results implementation in Romania Dan Eniu
- 12:00 - 12:20 Role of Surgery in Relapsed Ovarian Cancer Gheorghe Peltecu
- 12:20 - 12:30 Discussion
12:30 - 13:10
Break
Lunch Break
13:10 - 14:45
Key Session
Establishing the Global Gynecologic Oncology Innovation Hub
- 13:10 - 13:30 Clinical Trials in Romania: Building Regional Hub Capacity Volovat Constantin
- 13:30 - 13:50 Eastern Europe as an Innovation Hub for Clinical Trials: Opportunities and Challenges Benjamin Willan
- 13:50 - 14:10 Delivering Excellence in Clinical Trials: Romania’s Oncology Enrollment Success – An Industry Perspective Alina Codrescu
- 14:10 - 14:30 Bridging Clinical Research: From Academic Oncology to Industry and Vice Versa Mihaela Cristea
- 14:30 - 14:45 Panel Discussion and Audience Q&A
14:45 - 15:15
Symposium
Industry-Sponsored Symposium
- 14:45 - 15:00 Industry Symposium Pfizer: Comparative Real World Evidence on CDK4/6 Inhibitors: Insights From the P VERIFY Study on OS and rwPFS data Dana Lucia Stanculeanu
- 15:00 - 15:15 Industry Symposium Pfizer: IBRANCE in Routine Practice: Updated Insights from IOB Oana Trifanescu
15:15 - 15:30
Break
Coffee Break & Industry Exhibition
15:30 - 16:05
Symposium
Industry-Sponsored Symposium
- 15:30 - 15:50 Industry Symposium Baxter: Optimizing Treatment with Liposomal Doxorubicin: Lessons from Ovarian and Breast Cancer Cases Adelina Gheorghe
- 15:50 - 16:05 Industry Symposium Amgen: When Tumors Seem Immunologically Silent, Innovation Emerges: DLL3-Directed Bispecific Therapy Mircea Dediu
16:05 - 17:05
Round Table
Roundtable Discussion: Launching the Global Gynecologic Oncology Innovation Hub
Moderators Adelina Gheorghe, Elena Iovanescu, Elena Ioana Braicu
- 16:05 - 17:05 Panelists, Sevda Memet, Mihaela Cristea, Andrei Baciu, Jalid Sehouli, George Calin, Octavian Andronic
17:30 - 17:45
Closing
Closing Remarks
Jalid Sehouli, Dana-Lucia Stanculeanu, Elena-Ioana Braicu

